Francisco Requena -

The incredible robustness of the human genome

Genomics

In a recent interview, one of the most prolific Spanish researchers in the biomedical field, Carlos López Otín, stated the following:

Francisco Requena

Human genetics as a tool for drug discovery

drug-discovery

human-genetics

For children with a rare disease, an accurate diagnosis is crucial to provide advice, possible therapies and assess the potential risk for family members in future…

Francisco Requena

How many genes have been associated with cancer in PubMed?

API

R

bias

In the biomedical literature, it is common to find sentences like:

Francisco Requena

Extracting gene panels from the Genomics England Panelapp

web-scrapping

R

genetics

The Genomics England PanelApp provides panels of genes related to human disorders manually curated by healthcare experts. From a clinical and research perspective, this is a…

Francisco Requena

An introduction to ROC curves with animated examples

animation

R

machine-learning

Receiver operating characteristic (ROC) curves is one of the concepts I have struggled most. As a personal view, I do not find it intuitive or clear at first glance.…

Francisco Requena

An introduction to uncertainty with Bayesian models

animation

R

statistics

bayesian

In this post, we will get a first approximation to the “uncertainty” concept. First, we will train two models: logistic regression and its “Bayesian version” and compare…

Francisco Requena

Poisson distribution in genomics

animation

R

statistics

In this post, I will discuss briefly what is the Poisson distribution and describe two examples extracted from research articles in the genomics field. One of them based on…

Francisco Requena

Estimating pi value with Monte Carlo simulation

animation

R

# Load of libraries
library(tidyverse)
library(sp)
library(gganimate)

Francisco Requena

Exploring world flights with networks

networks

R

Recently, I started to read this free accessible book written by Albert-László Barabási. In the Chapter 4 of his book, it depicts the USA airport networks to represent…

Francisco Requena

Prediction of dengue cases through climate variables

machine-learning

R

Recently, I discovered a new website about competitions that it is not called Kaggle! Its name is Drivendata.

Francisco Requena